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Dr. Calum MacRae Selected as
One Brave Idea Winner

Meet Dr. MacRae

Meet Dr. MacRae

Dr. Calum MacRae, chief of cardiovascular medicine at Brigham and Women’s Hospital in Boston, and his world-class team were selected as the recipients of the One Brave Idea research award.

Dr. Calum MacRae is a cardiologist, geneticist and developmental biologist who graduated from Edinburgh and London before coming to Boston in 1991. After postdoctoral fellowships in human genetics with Drs. Christine and Jon Seidman and developmental biology with Dr. Mark Fishman, as well as additional clinical training in internal medicine and cardiology, he joined the Division of Cardiology at Massachusetts General Hospital in 2001. His research is focused on understanding the genetic contribution to common cardiovascular disease using human studies and complementary high-throughput biology in the zebrafish. His clinical interests include the management of inherited heart disease and cardiac involvement in systemic diseases. Dr. MacRae also is the Director of the Cardiology Fellowship Program and is responsible for Physician Scientist training initiatives at the CVRC.


Watch Dr. MacRae talk about One Brave Idea

Meet Dr. MacRae’s team

Euan Ashley, director of the Center for Inherited Cardiovascular Disease and member of the Stanford University Data Science Initiative

Albert-László Barabási, director, Center for Complex Network Research, Northeastern University

Elazer Edelman, director, Harvard-MIT Biomedical Engineering Center; director, Harvard-MIT Division of Health Sciences and Technology; professor of Medicine, Harvard Medical School and Health Sciences and Technology at MIT; and Cardiology faculty member, Brigham and Women’s Hospital

J. Michael Gaziano, chief of the Division of Aging, Brigham and Women’s Hospital and national principal investigator, the Million Veteran Program (MVP)

David Grayzel, Partner, Atlas Venture

Christopher O’Donnell, chief of Cardiology, West Roxbury V.A. and director, the Million Veteran Program (MVP)

Frederick ‘Fritz’ Roth, Canada research excellence chair, The Donnelly Centre, University of Toronto

Vasan Ramachandran, principal investigator, the Framingham Heart Study and chief, Preventive Medicine and Epidemiology, Boston University School of Medicine

About the Winning Idea

Dr. MacRae and his team plan to conduct a multi-phased research project to uncover new genetic, molecular and cellular markers associated with coronary heart disease (CHD) which could be used to screen the population at large to identify individuals at risk of developing CHD later in life.

The project would start with a study to collect genomic information, lifestyle data (sleep, activity, stress), key public health data (environmental and economic factors) and responses from people with CHD their families. This data will be cross-referenced against data from the Framingham Heart Study and the Million Veterans Program to validate novel traits that may be associated with the onset of CHD.

In the next phase of the project, Dr. MacRae and his team would discover new screening approaches to identify individuals at an early age who may be at risk of developing CHD. In the final phase of the research, Dr. MacRae and his team will focus on developing novel preventative or pre-disease therapeutic strategies with the ultimate goal of reducing the burden of CHD.

View the archived virtual press conference featuring Dr. MacRae discussing his breakthrough research idea.